Download e-book for kindle: Insulin Resistance and Cancer: Epidemiology, Cellular and by I. George Fantus

By I. George Fantus

This ebook stories the epidemiological institutions among insulin resistance and melanoma. this is often via stories of animal versions which help this courting and supply perception into capability mechanisms. numerous chapters then supply distinct exam of the mobile and molecular adjustments characterizing the insulin resistant country, reminiscent of hyperinsulinemia, irregular metabolism and hormone signaling, and the way those have interaction with a number of tumor features. for instance a few tumors current elevated amounts of the fetal kind of the insulin receptor, particular law of oxidative (Krebs’ cycle) metabolism (Warburg effect), in addition to mutations in numerous appropriate signaling pathways. ultimately, the medical implications of those facts are built-in with concerns of insulin “sensitization” and capability metabolic interventions to avoid and deal with melanoma. it's going to be famous that whereas a few cancers are linked to weight problems the authors the following have targeted totally on breast melanoma as a key and demanding model.

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Insulin Resistance and Cancer: Epidemiology, Cellular and Molecular Mechanisms and Clinical Implications: 1 (Energy Balance and Cancer) by I. George Fantus


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