Cancer Drug Resistance (Cancer Drug Discovery and - download pdf or read online

By Beverly A. (Ed.) Teicher,Beverly A. Teicher

prime specialists summarize and synthesize the most recent discoveries about the alterations that ensue in tumor cells as they strengthen resistance to anticancer medicinal drugs, and recommend new methods to fighting and overcoming it. The authors evaluation physiological resistance dependent upon tumor structure, mobile resistance in response to drug delivery, epigenetic alterations that neutralize or pass drug cytotoxicity, and genetic adjustments that regulate drug objective molecules by way of reducing or removing drug binding and efficacy. Highlights contain new insights into resistance to antiangiogenic remedies, oncogenes and tumor suppressor genes in healing resistance, melanoma stem cells, and the improvement of more desirable cures. There also are new findings on tumor immune get away mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

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Cancer Drug Resistance (Cancer Drug Discovery and Development) by Beverly A. (Ed.) Teicher,Beverly A. Teicher

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